Page 190 - WSAVA2018
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 25-28 September, 2018 | Singapore
Distraction techniques should be employed to avoid dog rubbing/licking off topical therapies.
Avoidance of ultraviolet light is important, especially during initial treatment phase. Sunscreen should be applied to non-pigmented areas and the dog should preferably be kept away from sun exposure.
Tattooing of the nasal planum is not recommended. Apart from potential topical chemical reaction to the ink, this method does not protect against actinic damage because the tattoo ink is injected into the dermis but actinic damage occurs mostly on the epidermis.
Generalised discoid lupus erythematosus
In the ten dogs reported, the breeds include two Chinese crested dogs, two Labrador retrievers, and one each of miniature pinscher, Leonberger, Shih Tzu and toy poodle.
The median age of onset is 9 years (range from 5 to 12 years). Both female and male are equally affected.
Clinical signs:
The skin lesions include generalised or multifocal plaques, scaling, follicular plugging and alopecia affecting mainly the neck, dorsum and lateral thorax. The plaques can progress to ulcers with subsequent healing resulting in central atrophic or hypertrophic scars. Both depigmentation and hyperpigmentation may be observed. Four of the ten dogs had plaques around mucocutaneous regions (mainly genitalia). A pattern of reticulated hyperpigmentation affecting the ventral abdomen and lateral thorax was seen in two of these dogs. No systemic signs were reported. Pruritus was reported in four dogs and pain in three. The main differential diagnoses are ischemic dermatopathies and hyperkeratotic erythema multiforme (“Old dog” EM).
Treatment options
A wide range of treatments has been reported to
be successful in the few cases including ciclosporin (with initial short course of glucocorticoids), hydroxychloroquine, topical tacrolimus and tetracycline/ niacinamide. However, relapses are common after medications were tapered.
The prognosis for DLE is good. Progression of FDLE and GDLE to systemic lupus erythematosus (SLE) has not been reported. There was a single case of a DLE variant to “clinical” SLE reported in one dog.
Selected references:
Pemphigus foliaceus
Bizikova P, Dean GA, Hashimoto T, Olivry T. Cloning and establishment of canine desmocollin-1 as a major autoantigen in canine pemphigus foliaceus. Veterinary Immunology Immunopathology,2012; 149: 197-207.
Olivry, T. A review of autoimmune skin diseases in domestic animals: Superficial pemphigus, Veterinary Dermatology,2006,17: 291-305
Gomez S, Morris DO, Rosenbaum MR, Goldschmidt MH.Outcome and complications associated with treatment of pemphigus foliaceus in dogs: 43 cases (1994-2000), Journal of the American Veterinary Medical Association: 2004, 224:8:1312-1316
Cutaneous lupus erythematosus
Banovic F, Linder KE, Uri M, Rossi MA, Olivry T. Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases), Veterinary Dermatology, 2016; 26(6): 488-e131
Wiemelt SP, Goldschmidt MH, Greek JS, Jeffers
JG, Wiemelt AP, Mauldin EA. A retrospective study comparing the histopathological features and response to treatment in two canine nasal dermatoses, DLE and MCP, Veterinary Dermatology, 2014; 15:6:341-348
Olivry T, Linder KE, Banovic F, Cutaneous lupus erythematosus in dogs: A comprehensive review. BMC veterinary research, 2018

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