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treatment period (unpublished observation). Owners
and particularly breeders should be warned about this possibility. Likewise, in cats implanted with deslorelin
the onset of sterility may be delayed beyond the
second month post-implantation. In a group of 7 tomcats implanted with the 9.4 mg deslorelin implant semen quality actually improved during the first month and then decreased gradually during the second month; complete sterility was achieved from day 40 post-treatment onwards with one cat actually still being potentially fertile at 70 days post-implantation (capable of ejaculating fertile semen when penile spikes had disappeared and serum testosterone had already reached basal levels)11.
Treatment of urinary incontinence in queens
Urinary incontinence is a relatively common condition in neutered bitches, with an incidence of 5-10% depending on breed and age at neutering. It is due to a deficiency of the urethral sphincter mechanism developing after gonadectomy. Treatment includes the use of alpha- adrenergic compounds (i.e. phenylpropanolamine) or short acting estrogens such as estriol13,14. Deslorelin also may be used as it has been shown to be effective in about 50% of cases. Urinary incontinence is anecdotally thought to be very rare or absent in cats. However,
the condition was recently reported in a Norwegian Forest queen neutered 6 months prior to the onset
of the condition15. A urethral sphincter incompetence was diagnosed and a 4.7 mg deslorelin implant was administered, which allowed full continence for a period of 15 months. Albeit a rare event, urinary incontinence may occur in the queen and deslorelin may be considered as a treatment.
· Romagnoli S, Salata P, Stelletta C, Milani C, Sontas H, Gelli D, Caldin M, Mollo A (2010). Postponement of puberty in male and female prepuberal cats with deslo- relin: a preliminary study. In: Proceed- ings 7th EVSSAR Congress. Louvain-La- Neive, Belgium, 14-15 May 2010
· Risso A, Corrada Y, Barbeito C, Diaz JD, Gobello C – Long-term release GnRH agonists postpone puberty in domestic cats. Reprod Dom Anim 2012 Dec;47(6):936-8. doi:10.1111/j. 1439- 0531.2012.01994.
· Cecchetto M, Salata P, Baldan A, Milani C, Mollo A, Fontaine C, Sontas H, Gelli D, De Benedictis G, Stelletta C, Romag- noli S. - Postponement of puberty in queens treated with deslorein. J Feline Med Surg. 2017 Dec;19 (12):1224-1230. doi: 10.1177/1098612X16688406. Epub 2017 Feb 14.
2. Carranza A, Faya M, Merlo ML, Batista P, Gobello C. Effect of GnRH analogs in postnatal domestic cats. Theriogenology. 2014 Jul 1;82(1):138-43. doi: 10.1016/j.theriogenology.2014.03.012. Epub 2014 Mar 20.
3. Carranza A, Faya M, Fernandez P, Barbeito
C, Gobello C. Histologic effect of a postnatal slow-release GnRH agonist on feline gonads. Theriogenology. 2015 May;83(8):1368-72. doi: 10.1016/j.theriogenology.2015.01.027. Epub 2015 Jan 31.
4. Munson L, Bauman JE, Asa CS et al Efficacy of the GnRH analogue deslorelin for suppression of oestrous cycles in cats. J Reprod Fertil Suppl. 2001;57:269-73.
· Pisu MC, Romagnoli S - Impiego clinico di un impianto di deslorelin nel gatto. Veterinaria, Anno 26 (1), February: 1-7, 2012
5. Goericke-Pesch S, Georgiev P, Atanasov A
et al. Treatment of queens in estrus and after estrus with a GnRH-agonist implant containing 4.7 mg deslorelin; hormonal response, duration of efficacy, and reversibility. Theriogenology. 2013;79(4):640-6.
6. Zambelli D, Bini C, Küster DG, Molari V, Cunto M. First deliveries after estrus induction using deslorelin and endoscopic transcervical in- semination in the queen. Theriogenology. 2015 Sep 15;84(5):773-8. doi: 10.1016/j.theriogenolo- gy.2015.05.010. Epub 2015 May 15.
· Novotny R, Cizek P, Vitasek R et al. Re- versible suppression of sexual activity in tomcats with deslorelin implant. Theriog- enology 2012; 78:848-857
7. Romagnoli S, Baldan A, Righetti C, Milani C, Mollo A, Stelletta C. - Semen quality and in- terval to sterility in tom cats treated with a 9.4 mg deslorelin implant. J Feline Med Surg. 2017 Feb;19(2):194-199. doi: 10.1177/1098612X15623985
· Romagnoli S, Baldan A, Ferro S, Righetti C, Scenna L, Gabai G, Badon T, Fontaine C, Mollo A, Stelletta C, Milani C - Length of efficacy and effect of implant location in adult tomcats treated with a 9.4 mg deslorelin subcutaneous implant. Sub- mitted to J Feline Med Surg, February 2018
· Reichler I, Hubler M, Jockle W, et al. The effect of GnRH analogs on urinary incontinence after ablation of the ova- ries in dogs. Theriogenology 2003; 60: 1207–1216.
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