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 25-28 September, 2018 | Singapore
G. Chondroprotective Supplements
Chondroprotectants are products proposed to protect the cartilage (against degradation).
· Glucosamine/Chondroitin
· Results take 4–8 weeks to develop. These improvements often last for several weeks after glucosamine supplements are discontinued.
· Studies and clinical experience in people and pets show that glucosamine/chondroitin are equally effective for treating OA when compared to NSAIDs without the side effects.
· Glucosamine is rapidly taken up by cartilage cells and helps stimulate the synthesis of synovial fluid and cartilage.
· Chondroitin sulfate is the major glycosamino- glycan found in cartilage; it also helps inhibit enzymes that are destructive to the joint.
· Glucosamine: ≥ 25 mg/kg, sid
· Chondroitin: ≥ 15—20 mg/kg
· Polysulfated glycosaminoglycan (Adequan®)
· S-adenosyl-methionine (SAM-e)
· Human clinical trials show SAMe effective in
· Positive results can persist for at least 2 years after treatment in people
· Rabbit studies show some chondroprotective effects, by increasing proteoglycan synthesis
· 18 mg/kg/day
H. Chinese Herbal Supplements
· Traditional Chinese Veterinary Medicine (TCVM) is an effective treatment to help complement current med- ications and improve pain management. Form the TCVM standpoint, pattern differentiation (Diagnosis) is important for the treatment strategy for OA pain. One diagnosis entity has different kind of patterns. Selections of herbal formulas are based on the pat- tern differentiation of the patient. As examples:
· Pain worse in heat/summer: Di Gu Pi San
· Pain worse in cold/winter: Loranthus Formula
· More stiffness than pain: Coix Formula
· Muscle soreness: Body Sore Conclusions
The conventional medical approach to OA focuses
upon the signs and symptoms of the disease. Integrative therapies with multimodal approach are becoming more utilized in veterinary patients and more popular with both clients and practitioners to address OA. When properly administered by adequately trained professionals, these modalities are incredibly effective and safe to patient. They also have less side effects when compared to medications. Often in our integrative practice, we find that adding in these modalities enables lower doses of conventional pain medications, more frequent patient monitoring and follow-up, and clients feel more proactive leading to greater client compliance and satisfaction.
· Only FDA-approved chondroprotectant in dogs
· Inhibit serine proteinases, which play a role in the
interleukin-1 mediated degradation of cartilage
proteoglycans and collagen.
· Inhibit some catabolic enzymes that degrade
collagen, proteoglycans, and hyaluronic acid
· Inhibit prostaglandin E synthesis.
· Reduce cartilage degradation by suppression of
inflammatory mediators and stimulation of GAG
synthesis.
· 2 mg/kg, twice weekly for 4 weeks, then once a
month.
· Omega 3 Fatty Acids
· Include: Alpha-linolenic acid (ALA), Eicosapentae- noic acid (EPA), Docosahexaenoic acid (DHA)
· When omega-3 FA replaces arachidonic acid (AA) in cell membranes, the inflammatory cas- cade is decreased.
· Diet high in omega-3 FA help with rheumatoid arthritis as well as OA.
· Implementation of a high-EPA diet together with an NSAID can reduce the amount of NSAID re- quired for the same effect by 25%
· 70-250 mg/kg, sid.
· Green-Lipped Mussel
· Natural source of GAGS including chondroitin,
as well as a number of other nutrients including complex proteins, amino acids, nucleic acids, naturally chelated minerals, fatty acids, and an inhibitor of prostaglandin synthesis, which makes it effective as an anti-inflammatory supplement, Glycoflex.
· Studies have confirmed improvement in human OA
· Study found that some owners perceive huge improvements in OA
· 30 mg/kg, sid-bid 164
treating OA
  43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS

















































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