Page 198 - WSAVA2018
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 25-28 September, 2018 | Singapore
was reduced to monthly in the remaining cases. Ninety percent of the cases were negative after two months of treatment, the remaining dogs after three months. The only dog needing every two week administration was
a dog on immunosuppressive therapy for pemphigus foliaceus, that became mite positive when the interval was increased to four weeks, but remained mite negative when afoxolaner was administered every two weeks. (Mueller 2017)
Sarcoptes:
Afoxolaner administered at the minimum dose of 2.5mg/ kg PO once a month for two treatments is effective for the treatment of infestation with Sarcoptes scabiei with a rapid and complete cure of mite infestation in one month and resolution of clinical signs in one to two months. (Beugnet 2016)
Otodectes:
A single oral administration of afoxolaner at the minimum dose of 2.5mg/kg PO is effective (>98%) in treating dogs with induced O. cynotis infestations with significantly fewer (P < 0.05) live mites present in the afoxolaner- treated group compared to the untreated group on Day 28. In this study, however, two out of eight afoxolaner- treated dogs were still infested with one and four ear mites, respectively on Day 28. (Carithers 2016)
Adverse Reactions:
Adverse reactions are rare. In a U.S. field study,
vomiting was seen in 17/415 (4.1%) cases. Five dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses.
Fluralaner (Bravecto®)
the imidacloprid and moxidectin spot-on after one month suggests that these dogs may not be comparable to the dogs presented with generalised demodicosis in Europe or North America. (Fourie 2015)
In a larger clinical study, 163 dogs of various breeds
with generalised demodicosis (63% with juvenile- and 37% with adult- onset of the disease) were treated with fluralaner once at a single dose of 25mg/kg. The majority of dogs (87%, all of the dogs with juvenile onset and most with adult-onset demodicosis) had negative skin scrapings after one month and all dogs were negative on scraping after two months. Adverse effects were not seen. (Karaś-Tęcza 2015).
Most interesting was the management of breeding bitches of 16 different breed types; German Shepherd, pug, Great Dane, Shih Tzu, shiba, malamute, Italian greyhound, Rhodesian ridgeback, mix breed that had produced repeated litters of puppies with generalized demodicosis. In this trial, all bitches were treated with
25 mg/kg fluralaner ten days prior to scheduled mating and three months later with a second dose. Fourteen bitches gave birth to litters that were clinically unaffected by demodicosis, although two puppies from one litter developed localised demodicosis. (Karaś-Tęcza 2016).
A recent study, that included 67 dogs, also demonstrated that fluralaner when given at the recommended dose for flea and tick prevention is also effective for the treatment of canine generalized demodicosis. In 46 individuals
with adult-onset demodicosis; 63%, 85% and 100% cure rates were observed after two, three and four months, respectively. In 21 dogs diagnosed with juvenile-onset demodicosis, in this same study, 81% and 100% cures were observed after two and three months, respectively. (Duangkaew 2017)
Sarcoptes:
Fluralaner at a dose of 25mg/kg once a month for a single treatment is effective for the treatment of infestation with Sarcoptes scabiei with a rapid and complete cure of mite infestation in one month and resolution of clinical signs in one to two months. (Taenzler 2016)
Otodectes:
A single oral administration of fluralaner at a dose
of 25mg/kg is effective for dogs with experimental
O. cynotis infestations with no mites present in the fluralaner-treated group compared to the untreated group on Day 28. In this study, however, two out of eight fluralaner-treated dogs were still infested with one to two ear mites on Day 14. (Taenzler 2016)
Fluralaner (4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5- (trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2- trifluoroethyl)amino]ethyl]-benzamide) is rapidly absorbed after single-dose oral administration, has a long elimination half-life, long mean residence time, relatively high apparent volume of distribution, and low clearance. For optimal absorption, bioavailability and efficacy, the drug should be administered with food. Numerous studies have demonstrated that a single fluralaner dose administered orally as chewable tablet provides flea and tick control for twelve weeks in dogs.
Demodex:
Fluralaner is effective for treatment of generalised demodicosis. In one study comparing a single dose of fluralaner to topically applied Advocate® (imidacloprid/ moxidectin) administered once a month; a reduction of 99.8% and 98% in mite numbers was achieved on Day 28 respectively. Skin scrapings were negative
in all dogs treated with fluralaner after 56 days. The excellent response of the dogs in this study receiving
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43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS





































































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