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 25-28 September, 2018 | Singapore
in multiple species (canine, feline, equine and human) and in multiple joint cell lines (chondrocytes and synovial lining cells). Millis et al have evaluated 8 hound dogs with chronic induced stifle OA. A recent study arm on this dog colony evaluated Dasuquin (Nutramax Labs), a nutraceutical containing Glu + CS + ASU + EGCG. Dogs treated with Dasuquin showed increased peak vertical force similar to that seen with various nonsteroidal anti- inflammatory drugs (NSAIDs) in a previous study arm.11 Although the small study population does not permit meaningful statistical analysis, these data suggest the need for larger scale and longer term evaluation of Dasuquin in the restoration of function and pain relief of dogs with chronic OA.
10. HEINECKE LF, GRZANNA MW. AU AY, ET AL. INHIBITION OF CYCLOOXYGENASE-2 EXPRESSION AND PROSTAGLANDIN E2 PRODUCTION IN CHONDROCYTES BY AVOCADO SOYBEAN UNSAPONIFIABLES AND EPIGALLOCATECHIN GALLATE. OSTEOARTHRITIS & CARTILAGE. 2010,18:220- 227.
11. MILLIS DL. UNPUBLISHED DATA, 2011.
D. Omega 3 Fatty Acids (docosahexaenoic acid, or DHA, and eicosapentaenoic acid, or EPA)
The mechanism of action of omega-3 fatty acid is to inhibit the conversion of Arachidonic acid (AA). AA
is an omega-6 fatty acid producing prostaglandins, leukotrienes, and thromboxanes. These eicosanoids have predominantly vasoactive and proinflammatory effects. Inhibiting the conversion of AA to these eicosanoids is the principal action of most NSAIDs
used to treat OA. Eicosanoids produced from EPA
and DHA are not potent inflammatory mediators, in contrast to those produced from AA. In a study of dietary supplementation with fish oil omega-3 fatty acids in osteoarthritic dogs showed a significant improvement
in weight-bearing (peak vertical force- PVF, improved 82%) as compared with the control-group (38%).12 The magnitude of improved weight-bearing (+ 5.6%) was of similar magnitude reported in many NSAID trials. A similar study alos showed that food supplemented with fish
oil omega-3 fatty acids improved the owner-assessed ability for the ability to rise from a resting position, play, and walk compared with control dogs (whom showed
no improvement).13 Another study showed that a diet supplemented with omega-3 fatty acid allowed for more rapid reduction in carprofen dosage in osteoarthritic dogs as compared to dogs fed a diet with a low omega-3 fatty acid content.14
12. ROUSH JK, CROSS AR, RENBERG WC, ET
AL. EVALUATION OF THE EFFECTS OF DIETARY SUPPLEMENTATION WITH FISH OIL OMEGA-3 FATTY ACIDS ON WEIGHT BEARING IN DOGS WITH OSTEOARTHRITIS. JAVMA. 2010,236:67-73.
13. ROUSH JK, DODD CE, FRITSCH DA, ET AL. MULTICENTER VETERINARY PRACTICE ASSESSMENT OF THE EFFECTS OF OMEGA-3 FATTY ACIDS ON OSTEOARTHRITIS IN DOGS. JAVMA. 2010,236:59-66.
14. FRITSCH DA, ALLEN TA, DODD CE, ET AL. A MULTICENTER STUDY OF THE EFFECT OF DIETARY SUPPLEMENTATION WITH FISH OIL OMEGA-3 FATTY ACIDS ON CARPROFEN DOSAGE IN DOGS WITH OSTEOARTHRITIS. JAVMA. 2010,236:535-539.
E. Green-Lipped Mussel (Perna Canaliculus)
Green-Lipped Mussel (GLM) is a shellfish from
New Zealand that obtains nutrients directly from
the phyto-plankton and minerals in sea water. In all,
there have been identified at least 50 nutrients in
the GLM, including complex proteins, amino acids, nucleic acids, naturally chelated minerals, enzymes, vitamins, glycosaminoglycans, and fatty acids. GLM has been shown to contain a unique omega-3 fatty acid, eicosatetraenoic acid (ETA), which appears to act as dual inhibitor of arachidonic acid oxygenation by both the cyclo-oxygenase (COX) and lipoxygenase pathways. In a study, the GLM-enriched diet modified gait in dogs with OA in that the peak vertical force significantly increased over the 60-d period when GLM was introduced into
a standardized control diet. [Rialland] Another study showed that GLM alleviated chronic orthopedic pain (veterinary-assessed mobility, owner-evaluated chronic pain index and pain VAS) in dogs compared to control group. [Hielm] Another study showed that GLM alleviated chronic orthopedic pain (veterinary-assessed mobility, owner-evaluated chronic pain index and pain VAS) in dogs compared to control group. [Hielm]
Rialland P, Bichot S, Lussier B, et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Canadian Journal of Veterinary Research. 2013;77(1):66-74.
Hielm-Björkman A, Tulamo R-M, Salonen H, Raekallio M. Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus). Evidence-based Complementary and Alternative Medicine: eCAM. 2009;6(3):365-373. doi:10.1093/ecam/nem136.
Curcumin
Curcumin is a polyphenol extract from the yellow spice, turmeric. Curcumin has been used for thousands of years in traditional Chinese and Ayurvedic medicine. Curcumin and various curcuminoid extracts have been studied extensively both in vitro and in vivo. In vitro studies have shown anti-inflammatory and anti-neoplastic effects including decreases in inflammatory cytokines (IL-6, IL-8, COX-2, PGE2, iNOS, MMP-3, MMP-9) and inhibition of NF-kB and TNF-α signaling. The major challenge with curcumin as an oral supplement is its extremely poor
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43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS






































































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