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WSV18-0167
REPRODUCTION
UPDATE ON CLINICAL USE OF AGLEPRISTONE IN BITCHES AND QUEENS
S. Romagnoli1
1Department of Animal Medicine, Production and Health, University of Padova, Agripolis, Legnaro, 35020 (PD), Italy
Introduction
The progesterone (P4) antagonist Aglepristone has
been available in Europe since early in this century. It
is an interesting and unique molecule with high affinity for progesterone (P4) receptors in vitro (three times greater than that of P4 in the canine species and nine times in the feline species). Aglepristone binds to uterine progesterone receptors without producing the biological effects of progesterone. Thus it can be used to block the action of P4 during pregnancy (fœtal resorption, abortion, induction of parturition) or non-pregnancy (uterine
and mammary conditions) in the bitch, and also in the queen. It is an oily injectable solution for subcutaneous administration at the dose of 10 mg/kg repeated on
two consecutive days, 24 hours apart. Aglepristone
is currently marketed with the indication to terminate pregnancy in the bitch. However, because of its novel mechanism of action, it has been the object of numerous studies over the last 2 decades and several indications have been proposed both in pregnant as well as non pregnant females as well as for endocrine, mammary and perineal conditions.
INDICATIONS FOR PREGNANT FEMALES
Early and late pregnancy termination - Aglepristone (AGL) is currently marketed with an indication for pregnancy termination in dogs at any time between day 0 (the day of mis/mating) and day 45. Efficacy is very high, 95-100% and side effects are extremely rare and characterized by a short-lasting pain at the injection
site 1, 2, 3. Treatment causes prevention of implantation
if performed prior to day 24 post-ovulation, embryonic resorption if performed between day 25 and 35 post- ovulation, and expulsion of well developed foetuses after day 35 post-ovulation4. Clinical signs vary from no sign when prevention of implantation or resorption occurs
to vulvar discharge, behavioural signs of parturition
and occasionally fever, loss of appetite and metritis following fetal expulsion. The leaflet’s indication to be used between day 0 and 45 is somewhat controversial due to the fact that a) bitches may ovulate up to 5-7 days following mating and still conceive, and b) treatment
in late pregnancy may take up to 9-10 days to achieve
an effect and therefore 45-day old foetuses may occasionally be still alive following a late treatment and either be expelled live around day 53-55 or die and not be expelled from the uterus. Therefore it is advisable
43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS
25-28 September, 2018 | Singapore
urine pH.
Patients that have an elective perineal urethrostomy have a favorable prognosis if attention is paid to proper surgical technique (i.e., urethral mucosa is sutured to skin). Occasionally, chronic stone forming patients will form a calculus that is too large to pass through the urethrostomy stoma.










































































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