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change over time as the wound progresses. The wound should also be constantly re-evaluated for options for definitive closure.
An exception to the rule of adding moisture can be in instances where there is no blood supply (in the case of extensive eschars) it may be prudent to keep the external aspect of a wound dry. If there is suspected
to be viable cutaneous tissues selective debridement and use of a moist healing technique can be employed. However, in the complete absence of viable cutaneous tissues this may not speed wound healing.
WSV18-0168
REPRODUCTION
USE OF DESLORELIN TO CONTROL REPRODUCTION IN CATS
S. Romagnoli1
1Department of Animal Medicine, Production and Health, University of Padova, Agripolis, Legnaro, 35020 (PD), Italy
Introduction
Deslorelin is a long acting synthetic agonist of gonadotropin-releasing hormone (GnRH) marketed for veterinary use in most western countries as a 2.1 mg, 4.7 mg and 9.4 mg implant; the 2.1 mg implant is marketed for use in horses (OvuplantTM), but its extra-label use in dogs is rather common, while the 4.7 (SuprelorinTM) and 9.4 (Suprelorin 12TM) mg implants are currently marketed in Europe and Oceania for the control of fertility and aggressiveness in male dogs but their extra-label use
in cats is becoming inceasingly common. This paper will review current and potential clinical applications of GnRH agonists in the control of feline reproduction and reproductive-related conditions.
Delaying puberty
Long acting GnRH agonists act by initially over- stimulating and subsequently down-regulating GnRH receptors at the pituitary gonadotropes, thereby suppressing the function of the Hypothalamic Pituitary Gonadal (HPG) axis and causing an arrest of secretion
of gonadal steroids as well as their by-products. When HPG suppression occurs prior to the onset of puberty, puberal estrus is delayed for as long as the action of the GnRH agonist persists. The postponement of puberty following prepuberal administration of deslorelin has been reported in cats1-5. We administered a 4.7 mg deslorelin implant to 9 prepuberal domestic shorthair European queens2: 3/9 queens showed signs of estrus (vaginal cheratinization) one week following implantation, but estrus signs gradually subdued and did not appear again for the following 14-25 months (at an age of 21-
33 months). Similar results in prepuberal queens were obtained when comparing the effect of the 4.7 mg deslorelin implant in 15 treated and 15 control 4-month old queens followed for a maximum of 18 months
with physical exams and vaginal cytology3. Average
age at puberty was 281+21 and 178+11 days in treated and control queens, respectively, while there was no difference in weight at the end of the study3. A delayed puberty may be obtained also by implanting post-natal kittens with a1.6 mg deslorelin implant, although the reported delay was only 63+3 weeks4,5, which is shorter than what was obtained by implanting queens right prior to puberty onset1,2. We have implanted 3 tomcats prior to puberty: although their post-GnRH serum testosterone
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