Page 684 - WSAVA2018
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 25-28 September, 2018 | Singapore
WSVA8-0079
GASTROENTEROLOGY
GLYCOGEN STORAGE DISEASE ASSOCIATED HYPOGLYCEMIA IN SHIH TZU
V. Wachirodom1
1Kasetsart University veterinary teaching hospital, Faculty of Veterinary Medicine- Kasetsart University, Bangkok, Thailand
INTRODUCTION
Severe and prolong hypoglycemia can be life- threatening. Therapy and prognosis depend on the underlying causes.
OBJECTIVES
To approach hypoglycemic episodes and diagnose glycogen storage disease (GSD).
METHODS
A 13-year-old, neutered female, Shih Tzu dog was presented with anorexia, weakness and diarrhea. Physical examination found abdominal pain and no detectable of neurologic deficit. Pancreatitis was confirmed with abnormal level of SNAP cPL. Although pancreatitis was resolved, the dog remained chronic, marked fasting hypoglycemia (<25 mg/dl).
RESULTS
To elucidate the cause of hypoglycemia, blood work and imaging techniques were conducted. Only mild hypoalbuminemia and moderate increased in liver enzymes were found. Cortisol level was normal. Serum insulin concentration was appropriate for the blood glucose concentration. Pre and postprandial bile acids were markly increased. Ultrasonography and CT scan demonstrated focal thickening of gastric wall and heterogenous parenchyma of liver, and heterogenous parenchyma of enlarged pancreas without mass effect in brain respectively. Histology of gastric, pancreatic
and liver samples obtained from exploratory laparotomy revealed gastric amyloidosis, lymphoplasmocytic gastritis, pancreatic hyperplasia and significant glycogen accumulation in hepatocytes without evidence of other hepatic lesions. Special staining of liver confirmed
GSD. The treatments were symptomatic treatment and frequent meals. The dog died after three years of diagnosis. Postmortem examination was not allowed
CONCLUSIONS
The case showed GSD is the cause of repeated hypoglycemic episodes that definitive diagnosed by histopathology. The disorder is clinically heterogeneous and progressive, and there is no effective treatment. Further study is required to improve our understanding of the disease progression and allow opportunities to investigate treatment interventions.
WSVA8-0090
INFECTIOUS AND EMERGING DISEASES
ASIA-PACIFIC SEROLOGICAL SURVEY OF CANINE HEARTWORM DISEASE BASED ON IN-CLINIC SNAP® HEARTWORM RT AND SNAP® 4DX® PLUS TEST RESULTS, 2013-2017
J. Braff1, L.W. Chang2, R. Chandrashekar1, J.S. Buch1
1IDEXX Laboratories Inc., Research and Development, Westbrook Maine, USA
2IDEXX Laboratories Inc., Marketing, Taipei, Taiwan R.O.C.
INTRODUCTION
Canine heartworm, caused by infection with mosquito- borne Dirofilaria immitis, poses a significant health
risk for dogs throughout the world. Although chemoprophylactic medications can reduce the incidence of this serious disease, heartworm continues to be prevalent in many parts of the Asia-Pacific region.
OBJECTIVES
The goal of this observational study was to evaluate Asia- Pacific regional geographic and temporal variation in canine heartworm antigen test results over a five-year period.
METHODS
Canine heartworm antigen test results spanning a period of five years (2013-2017) were obtained from an international database of SNAP® Heartworm RT and SNAP® 4Dx® Plus Test results from veterinary clinics. Repeat test results for a single patient and data from countries with less than one hundred available results were excluded. Data was included from at least 520 locations across twelve Asia-Pacific countries.
RESULTS
Table 1. Heartworm (HW) positive results by country.
      Country
 Test Count
 HW Positive
 HW Pos,% (95% CI)
 Australia
 9,469
 53
 0.6 (0.4-0.7)
 China
 432
 4
 0.9 (0.3-2.4)
 Hong Kong
 27,952
 1,514
 5.4 (5.2-5.7)
 India
 2,369
 25
 1.1 (0.7-1.6)
 Japan
 253,229
 3,573
 1.4 (1.4-1.5)
 Malaysia
 6,192
 568
 9.2 (8.5-9.9)
 Myanmar
 515
 76
 14.8 (11.8-18.1)
 Philippines
 950
 67
 7.1 (5.5-8.9)
 Singapore
 18,528
 488
 2.6 (2.4-2.9)
 South Korea
 9,810
 903
 9.2 (8.6-9.8)
 Taiwan
 131,729
 13,526
 10.3 (10.1-10.4)
 Thailand
 18,563
 561
 3.0 (2.8-3.3)
 TOTAL
 479,738
 21,358
 4.5 (4.4-4.5)
 CONCLUSIONS
Results from this study indicate that the proportion of positive heartworm antigen test results varies greatly by country. These findings underscore that dogs within the Asia-Pacific region are at risk for heartworm infection and the importance of regular screening and use of preventatives to mitigate this risk.
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43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS






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