Page 693 - WSAVA2018
P. 693

WSVA8-0075
INTERNAL MEDICINE (OTHER)
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA IN A DOG: A CASE REPORT
K. Kimram1, K. Siripattarapravat2, T. Jumnanslip1
1Kasetsart university veterinaty teaching hospital, Critical care unit, Bangkok, Thailand
2Faculty of veterinary medicine- Kasetsart university, Pathology, Bangkok, Thailand
An eight-year-old, intact male crossbred dog was presented neurological deficits with disoriented, left circling, nystagmus and left cranial nerve deficits. Blood profile was within normal limits. Superficial lymph nodes were appeared normal at palpation. Magnetic resonance imaging identified mass effect at extraparenchymal structures on sellar region nearby the pituitary gland which were hyperintense on T2-weighted images, contrast enhancement on T1-weighted images and
had perilesional hyperintensity on FLAIR images. Prednisolone was used as an anti-inflammatory drug and after that clinical sign was improved to conscious and circling was not detected. Thirty days later neurological signs progressively worsened, obtunded, inappetence, respiratory distress and the dog was died from respiratory arrest.
RESULTS
Gross examination revealed that the mass was located at sellar region of the brain. Histopathological evaluation reveal aggregated round cells and lymphocytes in
this region. This round cells had moderate amount
of cytoplasm, finely stripped nucleus and some of
these cells were bi-nucleated with nuclear molding. Immunohistochemical analysis was performed for CD3 and CD79a, and the tumor was characterized as T-cell- rich B-cell lymphoma.
CONCLUSIONS
We reported a rare case of primary CNS lymphoma, subtyping T-cell-rich B-cell lymphoma.
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  INTRODUCTION
Primary CNS lymphoma was extremely rare and that accounted for only 4% of all primary intracranial tumor. In canine, differentiation of lymphoma subtypes can
be performed by histopathological evaluation and immunophenotyping. Subtyping is crucial for prognosis and therapeutic plan.
OBJECTIVES
We describe clinical findings, management
and pathological diagnosis of a dog with CNS lymphoma. Subtyping of the tumor was done by immunohistochemistry for CD3 and CD79a.
METHODS
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