Page 694 - WSAVA2018
P. 694

 25-28 September, 2018 | Singapore
WSVA8-0076
INTERNAL MEDICINE (OTHER)
METASTASIS OF ORAL MALIGNANT MELANOMA IN A DOG: A CASE REPORT
K. Kimram1, K. Siripattarapravat2
1Kasetsart university veterinaty teaching hospital, Critical care unit, THAILAND, Thailand
2Faculty of veterinary medicine- Kasetsart university, Pathology, Bangkok, Thailand
INTRODUCTION
Malignant melanoma is a life-threatening disease characterized by highly aggressive biological behavior and often metastases to regional lymph nodes, lungs and also spread distantly to other organs.
OBJECTIVES
We report an advances clinical case of malignant melanoma that metastasized to brain and other organs and describe diagnostic tools that aid ante-mortem diagnosis.
METHODS
A fourteen-year-old, male, crossbred had been removed malignant melanoma from lip and neck that distant metastasis was not detected. Thirty days later the dog came with acute neurological deficits, disoriented and compulsive walking. The clinical sign had progressed rapidly to tetraparesis, head turn and cranial nerve deficits. Chest radiograph revealed diffuse pulmonary metastases. CT scanning showed brain edema with multiple masses and multiple nodules throughout lung field. Abdominal ultrasonography revealed a small hypoechoic nodule presented at spleen. The dog was treated with prednisolone and mannitol to relieve brain edema. Clinical sign was improved for a short period and progressively worsened and died from respiratory arrest.
RESULTS
Multiple black nodules were noted at omental fat, kidney, intercostal muscle, myocardium, lung, eye and brain. A microscopic examination revealed a spindle to polyhedral shape of neoplastic cell that had prominent vesicular nuclei located at the center. Some of these cells contained brown-pigmented granules in their cytoplasm. Histopathologic findings were diagnosed as metastatic malignant melanoma.
CONCLUSIONS
We demonstrated a rare case of disseminated metastatic of oral malignant melanoma that metastasized to brain, uvea and other organs. An investigation of the metastatic site of malignant melanoma could provide information for a further diagnosis and monitoring
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43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS
















































































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