Page 698 - WSAVA2018
P. 698

 25-28 September, 2018 | Singapore
WSVA8-0149
NEPHROLOGY
OUTCOMES OF HEMODIALYSIS IN CHRONIC KIDNEY DISEASE DOGS WITH UREMIC CRISIS SITUATIONS
K. Vichukit1, O. Detkalaya1, P. Thanaperm1, S. Kornkasem1, C. Lekcharoensuk1
1Kasetsart University, Kasetasrt University Veterinary Teaching Hospital- Veterinary medicine faculty, Bangkok, Thailand
INTRODUCTION
Uremic situations commonly develop in chronic kidney disease dogs. The complications associated with uremia including seizure, pneumonitis, cardiac arrest are situations shortened CKD patient life. The hemodialysis used to eliminate the uremic toxin and balances the electrolyte.
OBJECTIVES
The study was to determine the short-term outcome for chronic renal disease dogs with uremic crisis situations treated with hemodialysis compared to conservative treatment.
METHODS
WSVA8-0078
NEPHROLOGY
CORRELATION BETWEEN RENAL DAMAGE AND CLINICOPATHOLOGICAL CHANGES IN IMMUNE- COMPLEX GLOMERULONEPHRITIS AND NON- IMMUNE-COMPLEX GLOMERULONEPHRITIS IN DOGS
A. Yabuki1, T. Hamamoto1, Y. Ohara1, T. Shimokawa2, O. Yamato1
1Kagoshima University, Joint Faculty of Veterinary Medicine, Kagoshima, Japan
2Yamaguchi University, Joint Faculty of Veterinary Medicine, Yamaguchi, Japan
INTRODUCTION
Immune-complex glomerulonephritis (ICGN) and non- ICGN are major forms of chronic kidney disease (CKD) in dogs. However, the difference between the progression of CKD in ICGN and non-ICGN, is not fully understood.
OBJECTIVES
We aimed to clarify the association between pathological changes in the kidneys and clinicopathological changes in ICGN and non-ICGN, in dogs.
METHODS
Renal biopsy specimens (n=24) were obtained from dogs with protein-losing nephropathies, and these
were examined using light microscopy, electron microscopy, and immunofluorescence for the presence of immunoglobulins and complement 3. Severity of glomerular sclerosis (GS) and interstitial fibrosis (IF) were quantitatively evaluated, and correlations between these scores and clinicopathological parameters were statistically analyzed.
RESULTS
Eighteen and six cases were diagnosed with ICGN and non-ICGN, respectively. The GS score in ICGN showed no significant correlation with any clinicopathological parameter, including plasma concentrations of urea, creatinine (pCre), total protein and albumin, and urinary protein/creatinine ratio; however, the IF score showed a significant correlation with pCre. The GS score in non- ICGN showed a significant correlation with pCre, but
IF showed no correlation with any clinicopathological parameter.
CONCLUSIONS
Progression of CKD in ICGN was associated with IF severity, whereas in non-ICGN, it was associated with GS severity. This difference between ICGN and non-ICGN might be associated with the amount of proteinuria, which is severe in ICGN; the proteinuria is a major inducing factor for IF, which is in turn associated with decreased renal function.
    The study was retrospectively reviewed from September 2017 to October 2015 at Kasetsart University Veterinary Teaching Hospital (KUVTH), Faculty of Veterinary Medicine, Kasetsart University. Medical records of 21 uremic dogs were searched and divided into 2 groups of treatment. Hemodialysis treatment (HD) group was consisted of 8 dogs. Conservative treatment (CV)
group was consisted of 13 dogs admitted to KUVTH. Two sample t-test and Chi-square test were performed to determine the differences of age, body weight, gender and hematologic values between two groups of treatment. Method of survival analysis with Kaplan meier survival curve was used. The log-rank test was analyzed to determine the difference of median survival time between two groups of treatment.
RESULTS
Between two groups of treatment, body weight and serum creatinine of HD group were significantly higher (P<0.05) than CV group. The median survival time of uremic dogs treated with hemodialysis, 17 days (95%CI
= 12-19 days), was significantly different (P<0.05) from conservative treatment group, 3 days (95%CI = 2-6 days).
CONCLUSIONS
Hemodialysis is tools for prolong life and improving quality of life in CKD patient with acute uremic situation.
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43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS





























































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