Page 704 - WSAVA2018
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 25-28 September, 2018 | Singapore
WSVA8-0178
ONCOLOGY - ONCOSURGERY
EXPRESSION OF LEPTIN AND LEPTIN RECEPTOR IN CANINE MAMMARY TUMORS AND CORRELATION WITH OBESITY
A.A. Medeiros-Ronchi1, W.T. Blanca1, L.F. Gundim1, T.M. Wilson1, I.P. Castro1
1Federal University of Uberlandia, Animal Pathology, Uberlandia, Brazil
INTRODUCTION
Obesity is already considered as risk factor for mammary neoplasms in woman and female dogs. Leptin, a major protein that increases in concentration in obesity, may promote carcinogenesis of the mammary tissue through its interaction with the leptin receptor.
OBJECTIVES
In the present study, we analyzed leptin and leptin receptor (OBr) expression in canine mammary carcinomas (CMC) by immunohistochemistry and correlated with body condition score (BCS) and age of the bitch, tumor size and histological grade. Tumor size, age and histological grade were also related with BCS.
METHODS
The subjects were divided on the basis of their BCS: lean, optimal bodyweight, overweight or obese. Eighty- four bitches and ninety-five CMC specimens were randomly selected for the study.
RESULTS
Following microscopic examination, the samples were categorized as complex carcinomas (41% - 39/95) and simple carcinomas (59% - 56/95). Concerning to the body condition score (BCS), 9.52% bitches were lean (8/84), 29.76% bitches had optimal bodyweight (25/84), 33.33% had overweight (28/84) and 27, 39% bitches were obese (23/84) at the time of mastectomy. Obese animals presented mammary carcinomas at younger age and had larger tumors when compared to other body condition score (BCS). Leptin expression was not related to BCS; however, expression of ObR tended to be higher in tumors of bitches with higher BCS. Leptin expression was higher in older animals.
CONCLUSIONS
In conclusion, carcinomas of older animals expressed leptin and obese dogs presented mammary tumor at young age. Besides this larger carcinomas presented higher Obr expression
43RD WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND 9TH FASAVA CONGRESS
   CONCLUSIONS
These preliminary results showed significant variations in fatty acid profile between tumor and non-tumor tissue as well as within tumor tissues depending on tumor type. Further researches should address the correlation between alterations in the fatty acid profile of different lipid classes and tumor prognosis.
This work has been supported by the Croatian Science Foundation in the project IP-06-2016-3163) awarded to Kristina Starčević
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