Page 705 - WSAVA2018
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WSVA8-0180
ONCOLOGY - ONCOSURGERY
P53 OVEREXPRESSION IS ASSOCIATED WITH TO SHORTER SURVIVAL TIME OF BITCHES WITH MAMMARY TUMOR
A.A. Medeiros-Ronchi1, T.A. Moreira1, N.P. Soares1, T.R. Santos1, L.F. Gundim1, L.S. Santos1
1Federal University of Uberlandia, Animal Pathology, Uberlandia, Brazil
INTRODUCTION
Mammary tumor is the most important neoplasm in
intact female dogs. Mutations in p53 tumor suppressor gene lead to overexpression of p53 protein in mammary neoplasms and have been associated a worse prognosis in women, but its prognostic value in canine mammary tumors (CMT) is controversial.
OBJECTIVES
In the current study we evaluate the p53 expression in CMT and verify its correlation with tumor features and overall survival (OS), also evaluating the disease free interval (DFI) and tumor development interval in the mammary gland remnant (TDIMG) of bitches submitted to partial mastectomy.
METHODS
One hundred bitches were followed up for a minimum of two years. Determination of p53 expression was performed by immunohistochemistry using the streptavidin-biotin-peroxidase technique. Samples with more than 10% of labeled neoplastic cells were considered positive, and percentage and marking intensity were evaluated.
RESULTS
P53 overexpression was observed in 65% (65/100)
of the tumors. There was a correlation between p53 overexpression and histological subtype, which was higher in tubular and complex carcinomas (p = 0.017), and a higher marker score and higher labeling intensity was observed in high histological grade. However, there was no correlation between p53 expression and DFI (p = 0.441) and TDIMG (p = 0.240). The age of the dog at diagnosis was a factor that also influenced OS, being worse in bitches with more than eight years (p = 0.023).
CONCLUSIONS
This study demonstrated that the p53 overexpression in CMT should be considered as an important prognostic factor, related to a worse survival.
Your Singapore, the Tropical Garden City
WSVA8-0108
ONCOLOGY - ONCOSURGERY
RESECTION OF INSULINOMA USING BIPOLAR VESSEL-SEALING DEVICE IN A DOG
D.H. Park1, H.Y. Kang1, H.S. So1, J.S. Kang1, Y.U. Kim1, K.C. Lee1, N.S. Kim1, H. So1
1Chonbuk National University, Surgery of Veterinary Medicine, Iksan, Republic of Korea
INTRODUCTION
Tumors of pancreatic corpus are relatively rare and more difficult to remove than those of other pancreatic site with conventional ligating methods(CLM). In this case, pancreatic tumor located in pancreatic corpus was successfully resected using bipolar vessel-sealing device(BVSD).
OBJECTIVES
This case is to evaluate the prognosis after surgical resection using BVSD for pancreatectomy in insulinomas.
METHODS
An 11years old, 7.1kg, spayed female, Italian greyhound was referred to Chonbuk Animal Medical Center with ataxia. The result of serum chemistry test consistently revealed hypoglycemia. In Computed Tomography (CT), mass of pancreatic body about 10 x10mm was detected. Increased insulin concentration was revealed in immunoreactive insulin test.
After detecting dark and firm mass at pancreatic corpus, partial pancreatectomy was performed by using BVSD. Intraoperative complications were not observed. In postoperative histopathologic examination, pancreatic mass was definitely diagnosed with insulinomas.
RESULTS
Postoperative blood analysis showed normal glucose level. Although the patient had vomit on the day of surgery, clinical sign was improved after medical therapy. Since that time, the patient has been doing well without any complications.
CONCLUSIONS
Surgical resection using BVSD is safe and reduce intra/postoperative complications in insulinomas. This case suggested that BVSD could be good option in pancreatectomy.
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